- Tom Hanks as Robert Langdon, a professor of symbology at Harvard University.[1]
- Felicity Jones as Dr. Sienna Brooks, a doctor who helps Langdon escape.[2]
- Omar Sy as Christoph Bruder, head of the SRS team.[2]
- Ben Foster as Bertrand Zobrist, a transhumanist scientist, intent on solving the world's overpopulation problem.[3][4]
- Irrfan Khan as Harry "The Provost" Sims, head of The Consortium, helping Zobrist in his mission.[2]
- Sidse Babett Knudsen as Elizabeth Sinskey, head of the World Health Organization.[2]
- Ana Ularu as Vayentha, The Consortium's agent in Florence who has orders to follow Langdon.[4]
- Jon Donahue as Richard[4]
Directed by Ron Howard